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1

Synthesis and properties of 3′-amino-2′,4′-BNA, a bridged nucleic acid with a N3′→P5′ phosphoramidate linkage

Satoshi Obika, S.M. Abdur Rahman, Bingbing Song, Mayumi Onoda, Makoto Koizumi, Koji Morita, Takeshi Imanishi

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 342 KB

english, 2008

2

Synthesis of 2′-O,4′-C-methyleneuridine and -cytidine. Novel bicyclic nucleosides having a fixed C3, -endo sugar puckering

Satoshi Obika, Daishu Nanbu, Yoshiyuki Hari, Ken-ichiro Morio, Yasuko In, Toshimasa Ishida, Takeshi Imanishi

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 202 KB

english, 1997

3

Quantitative evaluation of the improvement in the pharmacokinetics of a nucleic acid drug delivery system by dynamic PET imaging with 18F-incorporated oligodeoxynucleotides

Mukai, Hidefumi, Ozaki, Daiki, Cui, Yilong, Kuboyama, Takeshi, Yamato-Nagata, Hiroko, Onoe, Kayo, Takahashi, Maiko, Wada, Yasuhiro, Imanishi, Takeshi, Kodama, Tetsuya, Obika, Satoshi, Suzuki, Masaaki,

Journal:

Journal of Controlled Release

Year:

2014

Language:

english

File:

PDF, 935 KB

english, 2014

4

Synthesis and properties of 2′-O,4′-C-spirocyclopropylene bridged nucleic acid (scpBNA), an analogue of 2′,4′-BNA/LNA bearing a cyclopropane ring

Yamaguchi, Takao, Horiba, Masahiko, Obika, Satoshi

Journal:

Chemical Communications

Year:

2015

Language:

english

File:

PDF, 1.43 MB

english, 2015

5

Serial incorporation of a monovalent GalNAc phosphoramidite unit into hepatocyte-targeting antisense oligonucleotides

Yamamoto, Tsuyoshi, Sawamura, Motoki, Wada, Fumito, Harada-Shiba, Mariko, Obika, Satoshi

Journal:

Bioorganic & Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 936 KB

english, 2016

6

Evaluation of the effects of chemically different linkers on hepatic accumulations, cell tropism and gene silencing ability of cholesterol-conjugated antisense oligonucleotides

Wada, Shunsuke, Yasuhara, Hidenori, Wada, Fumito, Sawamura, Motoki, Waki, Reiko, Yamamoto, Tsuyoshi, Harada-Shiba, Mariko, Obika, Satoshi

Journal:

Journal of Controlled Release

Year:

2016

Language:

english

File:

PDF, 1.23 MB

english, 2016

7

Synthesis of scpBNA-mC, -A and -G monomers, and evaluation of the binding affinities of scpBNA-modified oligonucleotides toward complementary ssRNA and ssDNA

Horiba, Masahiko, Yamaguchi, Takao, Obika, Satoshi

Journal:

Journal of Organic Chemistry

Year:

2016

Language:

english

File:

PDF, 739 KB

english, 2016

8

Biological applications of xeno nucleic acids

Morihiro, Kunihiko, Kasahara, Yuuya, Obika, Satoshi

Journal:

Molecular BioSystems

Year:

2016

Language:

english

File:

PDF, 784 KB

english, 2016

9

Synthesis and Properties of 7-Deazapurine- and 8-Aza-7-deazapurine-Locked Nucleic Acid Analogues: Effect of the Glycosidic Torsion Angle

Hara, Takashi, Kodama, Tetsuya, Takegaki, Yumi, Morihiro, Kunihiko, Ito, Kosuke Ramon, Obika, Satoshi

Journal:

Journal of Organic Chemistry

Year:

2017

Language:

english

File:

PDF, 950 KB

english, 2017

10

Evaluation of size-exclusion chromatography for the analysis of phosphorothioate oligonucleotides

Shimoyama, Atsuko, Fujisaka, Aki, Obika, Satoshi

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2017

Language:

english

File:

PDF, 417 KB

english, 2017

11

Cholesterol–GalNAc Dual Conjugation Strategy for Reducing Renal Distribution of Antisense Oligonucleotides

Wada, Fumito, Yamamoto, Tsuyoshi, Ueda, Tetsuya, Sawamura, Motoki, Wada, Shunsuke, Harada-Shiba, Mariko, Obika, Satoshi

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2018

Language:

english

File:

PDF, 389 KB

english, 2018

12

Synthesis of Therapeutic Oligonucleotides || Large-Scale Oligonucleotide Manufacturing

Obika, Satoshi, Sekine, Mitsuo

Year:

2018

Language:

english

File:

PDF, 570 KB

english, 2018

13

Synthesis of Therapeutic Oligonucleotides || Various Coupling Agents in the Phosphoramidite Method for Oligonucleotide Synthesis

Obika, Satoshi, Sekine, Mitsuo

Year:

2018

Language:

english

File:

PDF, 1.62 MB

english, 2018

14

Synthesis and properties of GuNA purine/pyrimidine nucleosides and oligonucleotides

Kumagai, Shinji, Sawamoto, Hiroaki, Takegawa-Araki, Tomo, Arai, Yuuki, Yamakoshi, Shuhei, Yamada, Katsuya, Ohta, Tetsuya, Kawanishi, Eiji, Horie, Naohiro, Yamaguchi, Takao, Obika, Satoshi

Journal:

Organic & Biomolecular Chemistry

Year:

2020

File:

PDF, 1008 KB

2020

15

Eine 2′,4′-verbrückte Nucleinsäure mit 2-Pyridon als Nucleobase: effiziente Erkennung einer C⋅G-Unterbrechung durch Triplexbildung mit einem Pyrimidinmotiv

Satoshi Obika, Yoshiyuki Hari, , Mitsuaki Sekiguchi, Takeshi Imanishi

Journal:

Angewandte Chemie

Year:

2001

Language:

german

File:

PDF, 91 KB

german, 2001

16

Stable Oligonucleotide-Directed Triplex Formation at Target Sites with CG Interruptions: Strong Sequence-Specific Recognition by 2′,4′-Bridged Nucleic-Acid-Containing 2-Pyridones under Physiological Conditions

Satoshi Obika, Yoshiyuki Hari, Mitsuaki Sekiguchi, Takeshi Imanishi

Journal:

Chemistry - A European Journal

Year:

2002

Language:

english

File:

PDF, 167 KB

english, 2002

17

A 2′,4′-Bridged Nucleic Acid Containing 2-Pyridone as a Nucleobase: Efficient Recognition of a C⋅G Interruption by Triplex Formation with a Pyrimidine Motif

Satoshi Obika, Yoshiyuki Hari, Mitsuaki Sekiguchi, Takeshi Imanishi

Journal:

Angewandte Chemie International Edition

Year:

2001

Language:

english

File:

PDF, 90 KB

english, 2001

18

A non-peptide CCR5 antagonist inhibits collagen-induced arthritis by modulating T cell migration without affecting anti-collagen T cell responses

Yi-Fu Yang, Takao Mukai, Ping Gao, Nobuya Yamaguchi, Shiro Ono, Hiroshi Iwaki, Satoshi Obika, Takeshi Imanishi, Takahiro Tsujimura, Toshiyuki Hamaoka, Hiromi Fujiwara

Journal:

European Journal of Immunology

Year:

2002

Language:

english

File:

PDF, 282 KB

english, 2002

19

Highly Stable Pyrimidine-Motif Triplex Formation at Physiological pH Values by a Bridged Nucleic Acid Analogue

S. M. Abdur Rahman, Sayori Seki, Satoshi Obika, Sunao Haitani, Kazuyuki Miyashita, Takeshi Imanishi

Journal:

Angewandte Chemie

Year:

2007

Language:

english

File:

PDF, 185 KB

english, 2007

20

Adjustment of the γ Dihedral Angle of an Oligonucleotide P3′→N5′ Phosphoramidate Enhances Its Binding Affinity towards Complementary Strands

Satoshi Obika, Mitsuaki Sekiguchi, Roongjang Somjing, Takeshi Imanishi

Journal:

Angewandte Chemie International Edition

Year:

2005

Language:

english

File:

PDF, 321 KB

english, 2005

21

Highly Stable Pyrimidine-Motif Triplex Formation at Physiological pH Values by a Bridged Nucleic Acid Analogue

S. M. Abdur Rahman, Sayori Seki, Satoshi Obika, Sunao Haitani, Kazuyuki Miyashita, Takeshi Imanishi

Journal:

Angewandte Chemie International Edition

Year:

2007

Language:

english

File:

PDF, 186 KB

english, 2007

22

Double-Stranded DNA-Templated Oligonucleotide Digestion Triggered by Triplex Formation

Satoshi Obika, Masaharu Tomizu, Yoshinori Negoro, Ayako Orita, Osamu Nakagawa, Takeshi Imanishi

Journal:

Year:

2007

Language:

english

File:

PDF, 801 KB

english, 2007

23

Synthesis of Light-Responsive Bridged Nucleic Acid and Changes in Affinity with Complementary ssRNA

Kunihiko Morihiro, Tetsuya Kodama, Masaru Nishida, Takeshi Imanishi, Satoshi Obika

Journal:

Year:

2009

Language:

english

File:

PDF, 320 KB

english, 2009

24

2′-O,4′-C-Aminomethylene-Bridged Nucleic Acid Modification with Enhancement of Nuclease Resistance Promotes Pyrimidine Motif Triplex Nucleic Acid Formation at Physiological pH

Prof. Hidetaka Torigoe, Dr. S. M. Abdur Rahman, Hiroko Takuma, Norihiro Sato, Prof. Takeshi Imanishi, Prof. Satoshi Obika, Kiyomi Sasaki

Journal:

Chemistry - A European Journal

Year:

2011

Language:

english

File:

PDF, 381 KB

english, 2011

25

Benzylidene Acetal Type Bridged Nucleic Acids: Changes in Properties Upon Cleavage of the Bridge Triggered by External Stimuli

Kunihiko Morihiro, Prof. Tetsuya Kodama, Prof. Satoshi Obika

Journal:

Chemistry - A European Journal

Year:

2011

Language:

english

File:

PDF, 425 KB

english, 2011

26

ChemInform Abstract: Studies on Novel and Chiral 1,4-Dihydropyridines. Part 6. Preparation of a Polymer-Supported 1,4-Dihydropyridine Having a Chiral Sulfinyl Group and Its Application to Biomimetic Reduction.

Satoshi Obika, Toshihiko Nishiyama, Satoshi Tatematsu, Masahiro Nishimoto, Kazuyuki Miyashita, Takeshi Imanishi

Journal:

Year:

1999

File:

PDF, 34 KB

1999

27

ChemInform Abstract: Synthesis of a Conformationally Locked AZT Analogue, 3′-Azido-3′-deoxy-2′-O,4′-C-methylene-5-methyluridine

Satoshi Obika, Jun-ichi Andoh, Tomomi Sugimoto, Kazuyuki Miyashita, Takeshi Imanishi

Journal:

Year:

1999

File:

PDF, 26 KB

1999

28

ChemInform Abstract: Facile Synthesis and Conformation of 3′-O,4′-C-Methyleneribonucleosides.

Satoshi Obika, Ken-ichiro Morio, Yoshiyuki Hari, Takeshi Imanishi

Journal:

Year:

2000

File:

PDF, 34 KB

2000

29

ChemInform Abstract: Synthesis of Conformationally Locked C-Nucleosides Having a 2,5-Dioxabicyclo[2.2.1]heptane Ring System.

Satoshi Obika, Yoshiyuki Hari, Ken-ichiro Morio, Takeshi Imanishi

Journal:

Year:

2000

File:

PDF, 30 KB

2000

30

ChemInform Abstract: Syntheses and Properties of Conformationally Restrained Nucleosides and Oligonucleotides Analogues

Journal:

Year:

2000

File:

PDF, 24 KB

2000

31

ChemInform Abstract: Syntheses and Properties of Novel Conformationally Restrained Nucleoside Analogues

Takeshi Imanishi, Satoshi Obika

Journal:

Year:

2000

File:

PDF, 24 KB

2000

32

ChemInform Abstract: Triplex-Forming Enhancement with High Sequence Selectivity by Single 2′-O,4′-C-Methylene Bridged Nucleic Acid (2′,4′-BNA) Modification.

Satoshi Obika, Yoshiyuki Hari, Tomomi Sugimoto, Mitsuaki Sekiguchi, Takeshi Imanishi

Journal:

Year:

2001

File:

PDF, 27 KB

2001

33

ChemInform Abstract: 3′-Amino-2′,4′-BNA: Novel Bridged Nucleic Acids Having an N3′→P5′ Phosphoramidate Linkage.

Satoshi Obika, Mayumi Onoda, Koji Morita, Jun-ichi Andoh, Makoto Koizumi, Takeshi Imanishi

Journal:

Year:

2002

File:

PDF, 27 KB

2002

34

BNAs: Novel Nucleic Acid Analogues with a Bridged Sugar Moiety

Takeshi Imanishi, Satoshi Obika

Journal:

Year:

2002

File:

PDF, 24 KB

2002

35

Synthesis of a Novel Bridged Nucleoside Bearing a Fused-Azetidine Ring, 3′-Amino-3′,4′-BNA Monomer.

Satoshi Obika, Jyun-ichi Andoh, Mayumi Onoda, Osamu Nakagawa, Akiko Hiroto, Tomomi Sugimoto, Takeshi Imanishi

Journal:

Year:

2003

File:

PDF, 59 KB

2003

36

Synthesis and Properties of a Novel Bridged Nucleic Acid with a P3′→N5′ Phosphoramidate Linkage, 5′-Amino-2′,4′-BNA.

Satoshi Obika, Osamu Nakagawa, Akiko Hiroto, Yoshiyuki Hari, Takeshi Imanishi

Journal:

Year:

2004

File:

PDF, 65 KB

2004

37

Triplex Formation Involving 2′-O,4′-C-Methylene Bridged Nucleic Acid (2′,4′-BNA) with 2-Pyridone Base Analogue: Efficient and Selective Recognition of C:G Interruption

Hidetaka Torigoe, Yoshiyuki Hari, Satoshi Obika, Takeshi Imanishi

Journal:

Year:

2004

File:

PDF, 59 KB

2004

38

Triplex Formation Involving 2′-O,4′-C-Methylene Bridged Nucleic Acid (2′,4′-BNA) with 1-Isoquinolone Base Analogue: Efficient and Selective Recognition of C:G Interruption

Hidetaka Torigoe, Yoshiyuki Hari, Satoshi Obika, Takeshi Imanishi

Journal:

Year:

2004

File:

PDF, 64 KB

2004

39

Bridged Nucleic Acids (BNAs) as a Basic Material for Genome Technology

Journal:

Year:

2005

File:

PDF, 8 KB

2005

40

Development of Bridged Nucleic Acid Analogues for Antigene Technology

Journal:

Year:

2005

File:

PDF, 8 KB

2005

41

Synthesis and Triplex-Forming Ability of 2′,4′-BNAs Bearing Imidazoles as a Nucleobase.

Yoshiyuki Hari, Satoshi Obika, Hiroyasu Inohara, Masahiro Ikejiri, Daisuke Une, Takeshi Imanishi

Journal:

Year:

2005

File:

PDF, 30 KB

2005

42

ChemInform Abstract: Synthesis of a Novel trans-3′,4′-BNA Monomer Bearing a 4,8-Dioxa-5-azabicyclo[5.3.0]decane Skeleton.

Tetsuya Kodama, Kensaku Sugaya, Takeshi Baba, Takeshi Imanishi, Satoshi Obika

Journal:

Year:

2009

File:

PDF, 33 KB

2009

43

ChemInform Abstract: Synthesis of Several Types of Bridged Nucleic Acids

S. M. Abdur Rahman, Takeshi Imanishi, Satoshi Obika

Journal:

Year:

2009

File:

PDF, 15 KB

2009

44

ChemInform Abstract: Synthesis and Evaluation of Novel 3,4-Epoxypiperidines as Efficient DNA Alkylating Agents.

Yuji Kawada, Tetsuya Kodama, Kazuyuki Miyashita, Takeshi Imanishi, Satoshi Obika

Journal:

Year:

2010

File:

PDF, 26 KB

2010

45

ChemInform Abstract: Bridged Nucleic Acids: Development, Synthesis and Properties

Satoshi Obika, S. M. Abdur Rahman, Aki Fujisaka, Yuji Kawada, Takeshi Baba, Takeshi Imanishi

Journal:

Year:

2010

File:

PDF, 15 KB

2010

46

ChemInform Abstract: Synthesis, RNA Selective Hybridization and High Nuclease Resistance of an Oligonucleotide Containing Novel Bridged Nucleic Acid (I) with Cyclic Urea Structure.

Masaru Nishida, Takeshi Baba, Tetsuya Kodama, Aiko Yahara, Takeshi Imanishi, Satoshi Obika

Journal:

Year:

2010

File:

PDF, 17 KB

2010

47

ChemInform Abstract: A Novel Bridged Nucleoside Bearing a Conformationally Switchable Sugar Moiety in Response to Redox Changes.

Takeshi Baba, Tetsuya Kodama, Kazuto Mori, Takeshi Imanishi, Satoshi Obika

Journal:

Year:

2011

File:

PDF, 25 KB

2011

48

Biologically Stable 2-5A Analogues containing 3′-O,4′-C-bridged Adenosine as Potent RNase L Agonists

Koji Morita , Masakatsu Kaneko, Satoshi Obika, Takeshi Imanishi, Yukio Kitade, Makoto Koizumi

Journal:

Year:

2007

Language:

english

File:

PDF, 227 KB

english, 2007

49

Syntheses of novel nucleoside dimer analogues containing an acyclic nucleoside and a carbamate linkage

Satoshi Obika, Yoshihiro Takashima, Yasuhide Matsumoto, Kiyonori Kuromaru, Takeshi Imanishi

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 226 KB

english, 1995

50

Synthesis and properties of 2′-O,4′-C-methyleneoxymethylene bridged nucleic acid

Yoshiyuki Hari, Satoshi Obika, Ryo Ohnishi, Ken Eguchi, Tomohisa Osaki, Hirofumi Ohishi, Takeshi Imanishi

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 231 KB

english, 2006